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  • Flg22 (P.s.tabaci) peptide

Flg22 (P.s.tabaci) peptide

Not For Human Use, Lab Use Only.

Cat.#: 319503

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Product Information

  • Product Name
    Flg22 (P.s.tabaci) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-TRLSSGLKINSAKDDAAGLQIA-OH
  • Sequence
    H-Thr-Arg-Leu-Ser-Ser-Gly-Leu-Lys-Ile-Asn-Ser-Ala-Lys-Asp-Asp-Ala-Ala-Gly-Leu-Gln-Ile-Ala-OH
  • Length (aa)
    22
  • Peptide Purity (HPLC)
    97.6%
  • Molecular Formula
    C94H165N29O33
  • Molecular Weight
    2229.47
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Flg22 is a conserved 22-amino acid peptide derived from the N-terminal region of flagellin, a structural protein of bacterial flagella. In the context of Pseudomonas syringae pv. tabaci (P.s.tabaci), this peptide, with the sequence TRLSSGLKINSAKDDAAGLQIA, functions as a potent pathogen-associated molecular pattern (PAMP). It is recognized by the plant receptor FLS2, initiating innate immune responses such as the activation of defense-related genes, including NHO1 in Arabidopsis.

    This flagellin-derived elicitor plays a critical role in nonhost resistance, a plant species-level defense mechanism. Experimental evidence demonstrates that a P. syringae pv. tabaci mutant lacking flagellin fails to induce the NHO1 gene and exhibits enhanced growth in Arabidopsis, indicating that flg22-triggered signaling is essential for limiting bacterial proliferation. In contrast, virulent pathogens like P. syringae pv. tomato DC3000 employ type III secretion system effectors to actively suppress this flg22-induced immune response.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Li X, Lin H, Zhang W, Zou Y, Zhang J, Tang X, Zhou JM. Flagellin induces innate immunity in nonhost interactions that is suppressed by Pseudomonas syringae effectors. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12990-5. doi: 10.1073/pnas.0502425102. Epub 2005 Aug 25. PMID: 16123135; PMCID: PMC1200263.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

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  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"