Recombinant FGFR2 protein (His tag)

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Recombinant Human FGFR-2 (Fibroblast growth factor receptor 2) fragment (aa 47-377) is a high-purity protein encompassing the Ig-like C2-type 2 and 3 domains. This fragment serves as an essential tool for investigating domain-specific functions in cell signaling, proliferation, and differentiation studies.

Fibroblast growth factor receptor 2 (FGFR-2) is a tyrosine kinase receptor critical for regulating cell proliferation, differentiation, migration, and apoptosis. It plays vital roles in embryonic development, limb bud formation, lung morphogenesis, osteogenesis, and skin development. The full-length protein localizes to the cell membrane as a single-pass type I membrane protein and undergoes rapid internalization and degradation upon ligand binding. FGFR-2 activates multiple signaling pathways including RAS/MAPK and AKT through phosphorylation of downstream effectors like PLCG1 and FRS2, with mutations leading to aberrant signaling associated with developmental disorders.