Feleucin-BO1 peptide

Feleucin-BO1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-FLGLLGSLL-NH2

H-Phe-Leu-Gly-Leu-Leu-Gly-Ser-Leu-Leu-NH2

9

95.59%

C₄₆H₇₈N₁₀O₁₀

931.17

Synthetic

Powder

Feleucin-BO1 was found in skin secretion, Oriental fire-bellied toad, Bombina orientalis, Asia.
Feleucin-BO1 is active against S. aureus (MIC 34 uM), but not Gram-negative bacteria or yeast.
Changes of residues G3, G6, and S7 to K increase peptide activity as well as activity spectrum. Changes of G3, G6, and S7 to lysines (i.e. feleucin-K3) enhance the antibacterial activity (MIC 7-14 uM) of the peptide.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Hou X, Du Q, Li R, et al. Feleucin-BO1: a novel antimicrobial non-apeptide amide from the skin secretion of the toad, Bombina orientalis, and design of a potent broad-spectrum synthetic analogue, feleucin-K3. Chem Biol Drug Des. 2015;85(3):259-67.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.