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Recombinant FBF1 protein (His tag)

Recombinant FBF1 protein (His tag)

Cat.#: 531779

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Special Price 294.7 USD

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Product Information

  • Product Name
    Recombinant FBF1 protein (His tag)
  • Documents
  • Description

    Recombinant Fem-3 mRNA-binding factor 1 (fbf-1) fragment (aa 165-568) from Caenororhabditis elegans, engineered for stability and solubility to support structural and biochemical studies of RNA regulation and germline development.

    Fem-3 mRNA-binding factor 1 (FBF-1) is a key RNA-binding protein in C. elegans that recognizes the 5'-UGUGCCAUA-3' consensus sequence in mRNA 3'-UTRs. It plays critical roles in germline stem cell maintenance, sex determination, and the sperm/oocyte switch by binding regulatory regions such as the fem-3 3'-UTR. FBF-1 also modulates expression of genes like gld-3, gld-1, and lip-1 through 3'-UTR interactions, contributing to germline proliferation, oogenesis, and suppression of tumor formation by preventing spermatocyte dedifferentiation. Localized to the cytoplasm, it functions in coordination with complexes like cye-1/cdk-2 to regulate germline development and cellular fate decisions.

  • Protein name
    Fem-3 mRNA-binding factor 1
  • Uniprot ID
    Q9N5M6
  • Gene Name
    fbf-1
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 165-568 aa (Q9N5M6) were fused with 6His tag.
  • Protein Species
    Caenorhabditis elegans
  • Molecular weight
    Predictes a molecular mass of 47.89 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 48 kDa band.
  • Purity
    >89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"