Recombinant EXOSX protein (His tag)

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Recombinant Human EXOSC10 Fragment (253-584) is a high-purity protein product encompassing the critical 3'-5' exonuclease and HRDC domains of Exosome complex component 10. This fragment serves as an essential tool for investigating the catalytic and regulatory functions of the RNA exosome complex in RNA processing, degradation, and DNA repair mechanisms.

EXOSC10 (Exosome complex component 10) is a catalytic subunit of the RNA exosome complex with 3'→5' exoribonuclease activity, playing pivotal roles in nuclear RNA maturation (including rRNA, snRNA, and snoRNA), degradation of non-coding transcripts, and cytoplasmic mRNA turnover. It participates in ribosome biogenesis as part of the small subunit processome, contributes to DNA damage response by recruiting repair proteins to double-strand breaks, and regulates toxic repeat RNA metabolism. The protein localizes predominantly to the nucleolus, with additional presence in the nucleoplasm and cytoplasm, reflecting its multifunctional involvement in RNA surveillance, cell proliferation, and developmental processes. The provided fragment (253-584) specifically targets the functional domains responsible for its exonuclease activity and structural interactions, enabling focused studies on these mechanisms.