Recombinant ETFB protein (His tag)

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Recombinant Human Electron Transfer Flavoprotein Subunit Beta (Beta-ETF), comprising residues 2-255, is a high-purity protein fragment engineered for stability and solubility. This product supports structural and functional studies of mitochondrial electron transport mechanisms, offering researchers a reliable tool for investigating fatty acid oxidation and amino acid metabolism pathways.

Electron Transfer Flavoprotein Subunit Beta (Beta-ETF), encoded by the ETFB gene in Homo sapiens, functions as a heterodimeric electron carrier critical for mitochondrial energy metabolism. It accepts electrons from multiple dehydrogenases, including acyl-CoA dehydrogenases, and transfers them to the respiratory chain via ETF-ubiquinone oxidoreductase. This process is essential for normal fatty acid oxidation and amino acid catabolism. The protein localizes to the mitochondrial matrix and binds an AMP molecule that contributes to its structural integrity. The provided fragment (residues 2-255) encompasses the functional domain, enabling detailed biochemical and structural analyses.