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Product Name
Recombinant EPC1 protein (His tag)
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Description
Recombinant human Enhancer of polycomb homolog 1 (EPC1) fragment (amino acids 1-291), a stable and soluble protein unit ideal for structural studies and biochemical assays investigating histone acetylation and DNA repair mechanisms.
Enhancer of polycomb homolog 1 (EPC1) is a key component of the NuA4 histone acetyltransferase complex, which catalyzes acetylation of nucleosomal histones H4 and H2A to enable transcriptional activation. This complex directly facilitates DNA double-strand break repair through homologous recombination and is essential for spermatid development via histone replacement during spermatogenesis. EPC1 specifically recruits MBTD1 to the NuA4 complex and localizes to the nucleus and cytoplasm, underscoring its multifaceted role in epigenetic regulation and genomic stability.
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Protein name
Enhancer of polycomb homolog 1
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Uniprot ID
Q9H2F5
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Gene Name
EPC1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-291 aa (Q9H2F5) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 35.92 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 41 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"