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Product Name
Recombinant ENL protein (His tag)
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Description
Recombinant Human Protein ENL (MLLT1) Fragment (1-145) is a high-purity, functional protein fragment encompassing the complete YEATS domain. This product is an essential tool for investigating chromatin recognition, histone modification binding, and transcriptional regulation mechanisms in epigenetic and cancer research.
Protein ENL, encoded by the MLLT1 gene, is a chromatin reader component of the super elongation complex (SEC) that enhances RNA polymerase II transcription by reducing polymerase pausing. It specifically binds acetylated and crotonylated histones, with a preference for crotonylated histones such as H3K27cr and H3K9cr20. ENL plays a critical role in acute myeloid leukemia by recognizing acetylated histones via its YEATS domain, thereby driving oncogenic gene transcription. The protein is localized to the nucleus, underscoring its involvement in nuclear epigenetic regulation and gene expression control.
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Protein name
Protein ENL
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Uniprot ID
Q03111
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Gene Name
MLLT1; ENL; LTG19; YEATS1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-145 aa (Q03111) were fused with C-terminal 6His tag.
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Sequence
MDNQCTVQVR LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK VVFWLHDSFP KPRRVCKEPP YKVEESGYAG FIMPIEVHFK NKEEPRKVCF TYDLFLNLEG NPPVNHLRCE KLTFNNPTTE FRYKLLRAGG VMVMPLEHHH HHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 18.16 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 19 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant ENL protein (His tag) SDS-PAGE
M: Marker; Lane 1: ENL; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"