Recombinant EHF protein (His tag)

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Recombinant human ETS homologous factor (hEHF) fragment (residues 207-300) is a high-purity, stable protein designed for structural and biochemical studies. This 94-amino acid fragment offers a soluble and well-folded unit ideal for investigating the molecular mechanisms of EHF, a key transcription factor involved in epithelial cell differentiation and proliferation.

ETS homologous factor (hEHF), encoded by the EHF gene, functions as a transcriptional activator that regulates epithelial cell differentiation and proliferation. It binds DNA sequences containing the GGAA core motif and may act as both an activator and repressor for specific gene subsets, modulating nuclear responses to MAPK signaling pathways. EHF plays a critical role in TNFRSF10B/DR5 expression regulation and has been implicated as a potential tumor suppressor in development and carcinogenesis. The protein localizes to the nucleus, consistent with its function in transcriptional regulation. The provided fragment (residues 207-300) represents a computationally selected stable region optimized for experimental applications.