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Product Name
Recombinant EDEM2 protein (His tag)
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Description
Recombinant ER degradation-enhancing alpha-mannosidase-like protein 2 (EDEM2) fragment (residues 22-507) from Homo sapiens, designed for structural and biochemical studies. This 486-amino acid fragment is optimized for stability and solubility, enabling researchers to investigate its critical role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins.
EDEM2 is a key component of the endoplasmic reticulum-associated degradation (ERAD) pathway, which selectively targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It functions in the endoplasmic reticulum lumen, where it is proposed to initiate ERAD by catalyzing the first mannose trimming step from Man9GlcNAc2 to Man8GlcNAc2 on substrate glycoproteins. EDEM2 may also recognize and bind exposed hydrophobic regions in misfolded proteins, facilitating their identification and processing within the ERAD quality control system.
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Protein name
ER degradation-enhancing alpha-mannosidase-like protein 2
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Uniprot ID
Q9BV94
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Gene Name
EDEM2; C20orf31; C20orf49
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 22-507 aa (Q9BV94) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 56.20 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 59 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"