EAK16-II peptide

EAK16-II peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Acetylation-AEAEAKAKAEAEAKAK-NH2

Acetylation-Ala-Glu-Ala-Glu-Ala-Lys-Ala-Lys-Ala-Glu-Ala-Glu-Ala-Lys-Ala-Lys-NH2

16

95.02%

C₇₀H₁₂₁N₂₁O₂₅

1656.83

Synthetic

Powder

The peptide EAK16-II is one of the first building blocks of environmentally responsive materials. It undergoes a solution-to-gel transition when transferred from a low to high ionic strength environment. This peptide forms cross-β fibrils that can support cell attachment and differentiation. The EAK16 series of low molecular weight peptides are versatile building blocks for drug delivery systems and tissue engineering scaffolds. EAK16-II could inhibit the self-sorting of EAKIIH6 in a concentration-dependent manner.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Wen Y, Roudebush SL, Buckholtz GA, Goehring TR, Giannoukakis N, Gawalt ES, Meng WS. Coassembly of amphiphilic peptide EAK16-II with histidinylated analogues and implications for functionalization of β-sheet fibrils in vivo. Biomaterials. 2014 Jun;35(19):5196-205. doi: 10.1016/j.biomaterials.2014.03.009. Epub 2014 Mar 28. PMID: 24680662.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.