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  • Dusquetide peptide

Dusquetide peptide

Not For Human Use, Lab Use Only.

Cat.#: 319835

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* Buy 1 get 1 free (?) What is TFA?

Special Price 101.70 USD

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Product Information

  • Product Name
    Dusquetide peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-RIVPA-NH2
  • Sequence
    H-Arg-Ile-Val-Pro-Ala-NH2
  • Length (aa)
    5
  • Peptide Purity (HPLC)
    95.91%
  • Molecular Formula
    C25H47N9O5
  • Molecular Weight
    553.7
  • CAS No.
    931395-42-5
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Dusquetide is a novel innate defense regulator (IDR) that modulates the innate immune system by binding to p62, a key adaptor protein downstream of innate immune sensing receptors such as toll-like receptors (TLRs). This modulation shifts cellular signaling from a pro-inflammatory response to an anti-inflammatory response while enhancing bacterial clearance and tissue healing. Dusquetide acts on both circulating and tissue-resident innate immune cells, making it effective even in immunosuppressed contexts.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Kudrimoti M, Curtis A, Azawi S, Worden F, Katz S, Adkins D, Bonomi M, Elder J, Sonis ST, Straube R, Donini O. Dusquetide: A novel innate defense regulator demonstrating a significant and consistent reduction in the duration of oral mucositis in preclinical data and a randomized, placebo-controlled phase 2a clinical study. J Biotechnol. 2016 Dec 10;239:115-125. doi: 10.1016/j.jbiotec.2016.10.010. Epub 2016 Oct 13. PMID: 27746305.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"