DRI-BCL10-P4 peptide
Not For Human Use, Lab Use Only.
Cat.#: 318872
Special Price 477.20 USD
Availability:
4 weeks
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Product Name
DRI-BCL10-P4 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
DRQIKIWFQNRRMKWKKeqlydllkGarkrsstr (lower case letters are on behalf of D-amino acid)
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Sequence
H-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-D-Glu-D-Gln-D-Leu-D-Tyr-D-Asp-D-Leu-D-Leu-D-Lys-Gly-D-Ala-D-Arg-D-Lys-D-Arg-D-Ser-D-Ser-D-Thr-D-Arg-OH
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Length (aa)
34
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Peptide Purity (HPLC)
95.2%
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Molecular Formula
C194H320N64O49S
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Molecular Weight
4365.06
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Source
Synthetic
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Form
Powder
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Description
DRI-BCL10-P4 is a BCL10 inhibitor peptide, interacted with BCL10, effectively disrupted BCL10 filament formation, selectively suppressed the growth of CB-SMOC-dependent cell lines (HBL1, TMD8 and SU-DHL4 cells), repressed NF-κB pathway activation in HBL1 and TMD8 cells but not in OCI-LY1 cells and induced apoptosis and cell cycle arrest of TMD8 and SU-DHL4 cells in a dose-dependent manner. DRI-BCL10-P4 suppressed the growth of BCL10-dependent DLBCL tumors in vivo. DRI-BCL10-P4 at 10 mg/kg significantly suppressed the growth of the BCL10-dependent cells (TMD8 and SU-DHL6 cell lines) but not the BCL10-independent tumor cells (OCI-LY1 cell line) in transplanted mouse models.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Bao W, Sun C, Sun X, et al. Targeting BCL10 by small peptides for the treatment of B cell lymphoma. Theranostics. 2020;10(25):11622-11636. Published 2020 Sep 19. doi:10.7150/thno.47533
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About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Peptide Property
- Analysed Sequence:H-DRQIKIWFQNRRMKWKKRTSSRKRAGKLLDYLQE-OH
- Chemical Formula:C194H320N64O49S
- Sequence length:34
- Extinction coefficient:12660 M-1cm-1
- GRAVY:-1.58
- Mw average:4365.06
- Theoretical pI:11.83
- Data Source:Peptide Property Calculator
GRAVY = grand average of hydropathy
X: Hydrophobic uncharged residues, like F I L M V W A and P
X: Basic residues, like R K H
X: Acidic residues, like D E
X: Polar uncharged residues, like G S T C N Q and Y
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"