DP1 peptide

DP1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-RFGRFLRKILRFLKK-OH

H-Arg-Phe-Gly-Arg-Phe-Leu-Arg-Lys-Ile-Leu-Arg-Phe-Leu-Lys-Lys-OH

15

95.78%

C₉₅H₁₆₀N₃₀O₁₆

1978.47

Synthetic

Powder

DP1 is an analog of the N-terminal fragment of chicken cathelicidin-2 (N-15 CATH-2). CATH-2 belongs to a major family of host-defence peptides called as cathelicidins and is an arginine-lysine rich peptide with both immunomodulatory and strong broad-spectrum antibacterial activity, but with a noticeable toxicity to mammalian cells. DP1 was found to be more effective and less toxic than the N-terminal CATH-2 peptide.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Sharma P, Sharma S, Joshi S, Barman P, Bhatt A, Maan M, Singla N, Rishi P, Ali ME, Preet S, Saini A. Design, characterization and structure-function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment. Sci Rep. 2022 Jul 14;12(1):12058. doi: 10.1038/s41598-022-16303-2. PMID: 35835842; PMCID: PMC9283491.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.