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  • DOTA-LM3 peptide

DOTA-LM3 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319677

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* Buy 1 get 1 free (?) What is TFA?

Special Price 649.00 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    DOTA-LM3 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    DOTA-Phe(4-Cl)-c[D-Cys-Tyr-D-Aph(Cbm)-Lys-Thr-Cys]-D-Tyr-NH2
  • Sequence
    DOTA-Phe(4-Cl)-c[D-Cys-Tyr-D-Aph(Cbm)-Lys-Thr-Cys]-D-Tyr-NH2
  • Length (aa)
    8
  • Peptide Purity (HPLC)
    95.45%
  • Molecular Formula
    C69H93ClN16O19S2
  • Molecular Weight
    1550.2
  • CAS No.
    1192362-32-5
  • PubChem CID
    168355559
  • Source
    Synthetic
  • Form
    Powder
  • Description
    DOTA-LM3 is a somatostatin antagonist peptide for peptide receptor radionuclide therapy (PRRT). It shows favorable biodistribution and higher tumor radiation doses than SSTR agonists in metastatic neuroendocrine neoplasms.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Baum RP, Zhang J, Schuchardt C, Müller D, Mäcke H. First-in-Humans Study of the SSTR Antagonist 177Lu-DOTA-LM3 for Peptide Receptor Radionuclide Therapy in Patients with Metastatic Neuroendocrine Neoplasms: Dosimetry, Safety, and Efficacy. J Nucl Med. 2021 Nov;62(11):1571-1581. doi: 10.2967/jnumed.120.258889. Epub 2021 Mar 5. PMID: 33674401; PMCID: PMC8612334.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"