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Product Name
Recombinant DNJA2 protein (His tag)
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Description
Recombinant Human DNAJA2 Fragment (1-72) is a high-purity protein fragment encompassing the J domain of DnaJ homolog subfamily A member 2. This fragment serves as a specialized tool for investigating the co-chaperone activity and protein folding mechanisms mediated by this critical domain.
The full-length DnaJ homolog subfamily A member 2 (DNAJA2) functions as a co-chaperone of Hsc70, stimulating ATP hydrolysis and facilitating the folding of unfolded proteins in conjunction with HSPA1A/B. This protein is membrane-associated through lipid-anchoring, positioning it at critical cellular interfaces where protein folding and quality control processes occur. The J domain contained within this fragment is essential for mediating interactions with Hsc70 and regulating its chaperone activity, making this recombinant fragment particularly valuable for studying specific domain-function relationships in protein folding pathways.
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Protein name
DnaJ homolog subfamily A member 2
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Uniprot ID
O60884
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Gene Name
DNAJA2; CPR3; HIRIP4
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-72 aa (O60884) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 9.92 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 11 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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