LHRH/GnRH peptide

LHRH/GnRH peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Pyr-HWSYGLRPG-NH2

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

9

97.5%

C₅₅H₇₅N₁₇O₁₃

1182.28

33515-09-2

638793

Synthetic

Powder

Luteinizing Hormone-Releasing Hormone (LH-RH) is a decapeptide originating from the hypothalamus that triggers the release of gonadotropins by interacting with specific receptors on pituitary cells. It plays a crucial role in regulating reproductive functions. Besides its role in the pituitary gland, LH-RH is found to have effects in peripheral organs like the prostate, endometrium, breast, and ovary, indicating its involvement in local tissue functions. LH-RH's presence has been noted in cancer cells and tumors of reproductive organs, suggesting a connection between LH-RH and conditions like prostate cancer and gynecological cancers, showcasing its significance beyond reproductive control.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Collado B, Carmena MJ, Cortés J, Schally AV, Prieto JC. Luteinizing hormone-releasing hormone antagonist Cetrorelix regulates the expression of Galphas and Galphai protein subunits and adenylate cyclase activity in rat ovary, breast and pituitary. Int J Oncol. 2004 Mar;24(3):725-30. PMID: 14767559.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.