Dermaseptin-S4 peptide

Dermaseptin-S4 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

ALWMTLLKKVLKAAAKAALNAVLVGANA

H-Ala-Leu-Trp-Met-Thr-Leu-Leu-Lys-Lys-Val-Leu-Lys-Ala-Ala-Ala-Lys-Ala-Ala-Leu-Asn-Ala-Val-Leu-Val-Gly-Ala-Asn-Ala-OH

28

95.02%

C₁₃₂H₂₂₉N₃₅O₃₂S

2850.4

151896-15-0

16130878

Synthetic

Powder

It showed activities against P. falciparum (antimalarial) as well as human sperm. Based on the primary structure, it can be fitted to a class L amphipathic alpha helix which places all K on the polar face. The N-terminal region is responsible for both oligomerization and hemolytic activity. NMR structures of two derivatives have been solved [2DD6 for K4-S4(1-13) and 2DCX for NC12-K4S4(1-13)]. Sequence has been corrected based on the original paper. 3/2015 GW. Dermaseptin-S4 was found in Sauvage's leaf frog, Phyllomedusa sauvagii, South America.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Mor A, Nicolas P. Isolation and structure of novel defensive peptides from frog skin. Eur J Biochem. 1994;219(1-2):145-54.
• Krugliak M, Feder R, Zolotarev VY, Gaidukov L, Dagan A, Ginsburg H, Mor A. Antimalarial activities of dermaseptin S4 derivatives. Antimicrob Agents Chemother. 2000 Sep;44(9):2442-51.
• Sztukowska MN, Roky M, Demuth DR. Peptide and non-peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms. Mol Oral Microbiol. 2019 Oct;34(5):169-182.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.