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Product Name
Recombinant DCK protein (His tag)
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Description
This product is a recombinant fragment of human Deoxycytidine kinase (dCK), encompassing amino acids 1-260. This carefully selected fragment represents a stable and soluble unit of this essential nucleoside kinase, making it ideal for structural studies, enzymatic assays, and biochemical characterization of nucleoside phosphorylation mechanisms.
Deoxycytidine kinase (dCK) is a crucial human enzyme that phosphorylates deoxyribonucleosides including deoxycytidine, deoxyguanosine, and deoxyadenosine. With broad substrate specificity that does not depend on substrate chirality, dCK serves as an essential enzyme for the activation of numerous nucleoside analog drugs widely used as antiviral and chemotherapeutic agents. The enzyme is primarily localized to the nucleus, where it plays a vital role in nucleotide metabolism and drug activation pathways. Its ability to phosphorylate various therapeutic nucleoside analogs makes it a significant target for cancer research and drug development studies.
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Protein name
Deoxycytidine kinase
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Uniprot ID
P27707
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Gene Name
DCK
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-260 aa (P27707) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 32.17 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 34 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"