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Recombinant DCAF5 protein (His tag)

Cat.#: 545705

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Product Information

  • Product Name
    Recombinant DCAF5 protein (His tag)
  • Documents
  • Description

    This product is a recombinant fragment of DDB1- and CUL4-associated factor 5 (also known as Breakpoint cluster region protein 2, BCRP2, or WD repeat-containing protein 22), encompassing amino acids 1-426. This stable and soluble fragment is ideal for structural studies and biochemical assays, offering researchers a reliable tool to investigate the protein's role in ubiquitination pathways.

    DDB1- and CUL4-associated factor 5 (DCAF5) is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4). The CRL4-DCAF5 complex plays a critical role in the ubiquitination of methylated non-histone proteins, including key regulators such as SOX2, DNMT1, and E2F1. This function highlights its importance in cellular processes like gene expression regulation, DNA methylation maintenance, and cell cycle control, making it a significant target for research in molecular biology and disease mechanisms.

  • Protein name
    DDB1- and CUL4-associated factor 5
  • Uniprot ID
    Q96JK2
  • Gene Name
    DCAF5; BCRG2; KIAA1824; WDR22
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 1-426 aa (Q96JK2) were fused with N-terminal 6His tag.
  • Sequence 
    MSKIKHHHHH HGGSMKRRAG LGGSMRSVVG FLSQRGLHGD PLLTQDFQRR RLRGCRNLYK KDLLGHFGCV NAIEFSNNGG
QWLVSGGDDR RVLLWHMEQA IHSRVKPIQL KGEHHSNIFC LAFNSGNTKV FSGGNDEQVI LHDVESSETL DVFAHEDAVY
GLSVSPVNDN IFASSSDDGR VLIWDIRESP HGEPFCLANY PSAFHSVMFN PVEPRLLATA NSKEGVGLWD IRKPQSSLLR
YGGNLSLQSA MSVRFNSNGT QLLALRRRLP PVLYDIHSRL PVFQFDNQGY FNSCTMKSCC FAGDRDQYIL SGSDDFNLYM
WRIPADPEAG GIGRVVNGAF MVLKGHRSIV NQVRFNPHTY MICSSGVEKI IKIWSPYKQP GCTGDLDGRI EDDSRCLYTH
EEYISLVLNS GSGLSHDYAN QSVQEDPRMM AFFDSLVRRE
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 49.42 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 49 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant DCAF5 protein (His tag) SDS-PAGE

    Recombinant DCAF5 protein (His tag) SDS-PAGE

    M: Marker; Lane 1: DCAF5; Lane 2: BSA

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"