Recombinant DAF19 protein (His tag)

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This product is a recombinant protein fragment of the RFX-like transcription factor daf-19 (Abnormal dauer formation protein 19) from Caenorhabditis elegans, encompassing residues 442-771. This 330-amino acid fragment has been computationally optimized for stability and solubility, making it ideal for structural studies, biochemical assays, and functional investigations of transcription factor mechanisms.

The full-length daf-19 protein functions as a transcription factor in Caenorhabditis elegans, primarily localizing to the nucleus. It regulates genes in ciliated sensory neurons, activating expression of shared ciliary components while not affecting cell-type-specific expression. DAF-19 works in coordination with transcription factor atf-7 to modulate serotonergic responses in ADF neurons when exposed to pathogenic food sources. Additionally, isoform c plays a specialized role in male mating behavior through functional specialization of PKD ciliated sensory neurons. This protein fragment provides researchers with a valuable tool for studying the molecular mechanisms underlying sensory neuron function and transcriptional regulation in nematode systems.