Recombinant DAB2 protein (His tag)

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Recombinant Human Disabled homolog 2 (DAB2) Fragment (aa 32-182) is a high-purity, stable protein designed for studying clathrin-mediated endocytosis and cell signaling pathways. This 151-amino acid fragment, derived from the Homo sapiens DAB2 protein, offers a soluble and functional unit ideal for biochemical assays, structural analysis, and investigating its roles in receptor trafficking and tumor suppression.

Disabled homolog 2 (DAB2) is an adapter protein that acts as a clathrin-associated sorting protein (CLASP), essential for clathrin-mediated endocytosis of cargo proteins like the LDL receptor, integrin beta-1, and CFTR. It binds clathrin and phosphatidylinositol 4,5-bisphosphate, facilitating the recruitment of cargo to clathrin-coated pits, often independently of the AP-2 complex. DAB2 is involved in key signaling pathways, including TGF-beta receptor signaling, where it promotes SMAD2 phosphorylation, and Wnt/beta-catenin signaling, where it may inhibit canonical pathways by stabilizing the beta-catenin destruction complex. It also plays roles in cellular differentiation, epithelial to mesenchymal transition during embryogenesis, and myeloid cell differentiation, and it may function as a tumor suppressor. Subcellularly, DAB2 localizes to the cytoplasm, clathrin-coated vesicles, and clathrin-coated pits, with dynamic redistribution during mitosis.