DA-JC4 peptide
Not For Human Use, Lab Use Only.
Cat.#: 319805
Special Price 499.00 USD
Availability:
5 weeks
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Product Name
DA-JC4 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
Y-{Aib}-EGTFTSDYSIYLDKQAA-{Aib}-EFVNWLLAGGPSSGAPPPSKKKKKK-NH2
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Sequence
Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Tyr-Leu-Asp-Lys-Gln-Ala-Ala-{Aib}-Glu-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH2
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Length (aa)
45
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Peptide Purity (HPLC)
95%
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Molecular Formula
C225H346N56O65
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Molecular Weight
4875.49
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CAS No.
2315504-40-4
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PubChem CID
172878539
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Source
Synthetic
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Form
Powder
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Description
DA-JC4 is a novel dual agonist targeting both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors. This synthetic peptide has been optimized to cross the blood-brain barrier effectively. In experimental models, DA-JC4 demonstrates the ability to modulate insulin signaling pathways in neural tissues, as evidenced by its effects on phospho-IRS1Ser1101 and phospho-AktSer473 levels. The peptide also influences tau protein phosphorylation states in cerebral cortex and hippocampal regions.
At the cellular level, DA-JC4 exhibits modulatory effects on neuroinflammatory responses, as observed through its impact on GFAP-positive astrocytes and IBA1-positive microglia populations. The peptide influences apoptotic signaling pathways, demonstrated by its regulation of the BAX/Bcl-2 ratio. These molecular effects occur at relatively low concentrations (10 nmol/kg), suggesting high potency in biological systems.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Shi L, Zhang Z, Li L, Hölscher C. A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model. Behav Brain Res. 2017 Jun 1;327:65-74. doi: 10.1016/j.bbr.2017.03.032. Epub 2017 Mar 23. PMID: 28342971.
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About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"