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  • D-Pro-Phe-Arg-Chloromethylketone peptide

D-Pro-Phe-Arg-Chloromethylketone peptide

Not For Human Use, Lab Use Only.

Cat.#: 319787

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* Buy 1 get 1 free (?) What is TFA?

Special Price 519.00 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    D-Pro-Phe-Arg-Chloromethylketone peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence
    H-D-Pro-Phe-Arg-Chloromethylketone
  • Length (aa)
    3
  • Peptide Purity (HPLC)
    95%
  • Molecular Formula
    C21H31ClN6O3
  • Molecular Weight
    450.96
  • CAS No.
    88546-74-1
  • PubChem CID
    10456438
  • Source
    Synthetic
  • Form
    Powder
  • Description

    D-Pro-Phe-Arg-Chloromethylketone is a synthetic peptide inhibitor that irreversibly targets the amidolytic activity of activated factor XII (FXIIa) and plasma kallikrein-mediated FXII activation. This compound has been demonstrated to block FXIIa-driven coagulation and inflammatory pathways in experimental models, effectively reducing pathological thrombosis and edema formation without interfering with hemostasis. Its mechanism involves covalent modification of the active site serine residue, rendering the protease inactive.

    Studies utilizing D-Pro-Phe-Arg-Chloromethylketone have shown its efficacy in protecting against cerebral ischemia in transient middle cerebral artery occlusion models, polyphosphate-induced vascular leakage, and anaphylaxis-related hypotension. The inhibitor's specificity for FXIIa and plasma kallikrein positions it as a valuable tool for investigating contact system biology, particularly in dissecting the roles of these proteases in thrombotic and inflammatory processes while maintaining normal hemostatic function.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Nickel KF, Long AT, Fuchs TA, Butler LM, Renné T. Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20. doi: 10.1161/ATVBAHA.116.308595. Epub 2016 Nov 10. PMID: 27834692.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"