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  • [D-Leu2]deltorphin peptide

[D-Leu2]deltorphin peptide

Not For Human Use, Lab Use Only.

Cat.#: 317050

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Product Information

  • Product Name
    [D-Leu2]deltorphin peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Y{d-Leu}​FADVASTIGDFFHSI-NH₂​
  • Sequence
    H-Tyr-d-Leu-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-Phe-His-Ser-Ile-NH2
  • Length (aa)
    17
  • Peptide Purity (HPLC)
    95.6%
  • Molecular Formula
    C91H128N20O25
  • Molecular Weight
    1902.1
  • Source
    Synthetic
  • Form
    Powder
  • Description

    [D-Leu2]deltorphin is a 17-amino acid opioid peptide isolated from methanol extracts of the skin of the Brazilian hylid frog Phyllomedusa burmeisteri. Its sequence is Tyr-D-Leu-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-Phe-His-Ser-Ile-NH2, featuring a D-leucine residue at position 2. This peptide belongs to the deltorphin subfamily, characterized by the presence of a D-amino acid in the second position, which is crucial for bioactivity in related peptides.

    The natural [D-Leu2]deltorphin exhibits low affinity for δ-opioid binding sites in both peripheral tissues and the central nervous system. However, a shorter synthetic amidated analogue, [D-Leu2]deltorphin(1-10), demonstrates significant agonistic potency and selectivity for δ-opioid receptors, comparable to enkephalins. Another truncated analogue, [D-Leu2]deltorphin(1-7), shows minimal activity peripherally but binds to both δ and μ opioid sites in rat brain membranes. This peptide is part of a group of natural animal-derived peptides containing D-amino acids, all found at position 2 of their sequences.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Barra D, Mignogna G, Simmaco M, Pucci P, Severini C, Falconieri-Erspamer G, Negri L, Erspamer V [D-Leu2]deltorphin, a 17 amino acid opioid peptide from the skin of the Brazilian hylid frog, Phyllomedusa burmeisteri Peptides 1994;15(2):199-202
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

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  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"