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catalog peptide: D-Cateslytin

D-Cateslytin

Cat.#: 318730

Special Price 266.5 USD

Availability: 1-2 weeks

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Description
D-Cateslytin
Quantity/Unit 1 Vial
Sequence RSMRLSFRARGYGFR (all D-type amino acids)
Three letter code H-Arg-Ser-Met-Arg-Leu-Ser-Phe-Arg-Ala-Arg-Gly-Tyr-Gly-Phe-Arg-OH
Length 15
Peptide Purity (%) 95.2
Molecular Formula C81H130N30O19S1
Molecular Weight 1860.18
Source Synthetic
Additional Information The peptide cateslytin (RSMRLSFRARGYGFR) produced by enzymatic degradationof stress proteins is remarkably active against a large number of microorganisms including Plasmodium Falciparum responsible for Malaria. Its mode of action on membranes mimicking the external negatively charged membrane of these microorganisms has been studied by circular dichroism, infra-red (attenuatedtotal reflection), high-resolution magic angle sample spinning and wide line solid state NMR, patch clamp and molecular dynamics. The peptide, which is unstructuredin solution, adopts an aggregated beta sheet structure upon interacting with negatively charged membranes. D-Cateslytin (D-Ctl), a new epipeptide derived from L-Cateslytin, where all L-amino acids were replaced by D-amino acids. D-Ctl emerges as a potent, safe and robust peptide antimicrobial with undetectable susceptibility to resistance. Using Escherichia coli as a model, D-Ctl targets the bacterial cell wall leading to the permeabilization of the membrane and the death of the bacteria. Overall, D-Ctl offers many assets that make it an attractive candidate for the biopharmaceutical development of new antimicrobials either as a single therapy or as a combination therapy as D-Ctl also has the remarkable property to potentiate several antimicrobials of reference such as cefotaxime, amoxicillin and methicillin.
Storage Guidelines Ideally D-Cateslytin should be stored in a freezer at or below -9C. D-Cateslytin should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
Terms Please do not use the peptide for human consumption. NovoPro will immediately deny any order that we feel will be used outside of the scope of its intended purpose.
References

Zaet A, Dartevelle P, Daouad F, et al. D-Cateslytin, a new antimicrobial peptide with therapeutic potential. Scientific Reports. 2017;7(1). doi:10.1038/s41598-017-15436-z.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"