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Product Name
Recombinant CYH3 protein (His tag)
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Description
Recombinant Human Cytohesin-3 (ARNO3/Grp1) Fragment (aa 1-400) is a high-purity protein designed for studying guanine-nucleotide exchange on ARF1 and ARF6. This fragment encompasses the full SEC7 and PH domains, making it an ideal tool for investigating domain-specific functions in cellular signaling and membrane dynamics.
Cytohesin-3 (encoded by the CYTH3 gene) is a key regulator of ADP-ribosylation factors (ARFs), promoting the activation of ARF1 and ARF6 through GDP-to-GTP exchange. It plays a critical role in epithelial polarization and cellular trafficking. The protein localizes to the cytoplasm, cytosol, and dynamically translocates to the cell membrane, particularly to regions enriched in phosphatidylinositol 3,4,5-trisphosphate. It is also found at adherens and tight junctions, underscoring its importance in cell junction integrity and signaling pathways.
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Protein name
Cytohesin-3
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Uniprot ID
O43739
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Gene Name
CYTH3; ARNO3; GRP1; PSCD3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-400 aa (O43739) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 48.01 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 54 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"