Ctriporin peptide

Ctriporin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

FLWGLIPGAISAVTSLIKK

Phe-Leu-Trp-Gly-Leu-Ile-Pro-Gly-Ala-Ile-Ser-Ala-Val-Thr-Ser-Leu-Ile-Lys-Lys

19

96.3%

Synthetic

Powder

C-terminal amidation. Active against S. aureus (MRSA), B. thuringiensis, B. subtilis, M. luteus (MICs 5-10 ug/ml), and C. albicans (MIC 20 ug/ml). However, the peptide is inactive against E. coli or P. aeruginosa (>100 ug/ml). The peptide showed a rapid killing probably tarrgeting bacterial membranes. In 30% or 70% TFE, it adopted a helical structure based on CD. Detailed 3D structures of Ctriporin in micelles have been determined by NMR (Bandyopadhyay S et al., 2014). Of note, the structure in complex with SDS differs from that in DPC. It was proposed that such differences might explain peptide selectivity. Animal model:mouse: topical treatment could cure skin infection. Updated 12/2014. Ctriporin has Antibacterial, Antifungal activity. Ctriporin was found in venom, Chaerilus tricostatus.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Fan Z, Cao L, He Y, et al. Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus. Antimicrob Agents Chemother. 2011;55(11):5220-9.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.