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Product Name
Recombinant CSDC2 protein (His tag)
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Description
Recombinant Human Cold Shock Domain-containing Protein C2 (CSDC2) Fragment (aa 48-153) is a high-purity protein designed for studying RNA-binding mechanisms. This fragment fully encompasses the conserved Cold Shock Domain (CSD), making it an ideal tool for investigating histone mRNA regulation and neural development pathways in experimental models.
The full-length Cold Shock Domain-containing Protein C2 (CSDC2), also known as RNA-binding protein PIPPin, is an RNA-binding factor that specifically targets the 3'-UTR regions of histone H1 and H3.3 mRNAs, including their polyadenylation signals. It is implicated in the negative regulation of histone variant synthesis during brain development, playing a potential role in epigenetic and transcriptional control. The protein localizes to both the nucleus and cytoplasm, with PIPPin-RNA complexes primarily nuclear, underscoring its involvement in post-transcriptional RNA processing and nuclear-cytoplasmic coordination.
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Protein name
Cold shock domain-containing protein C2
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Uniprot ID
Q9Y534
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Gene Name
CSDC2; PIPPIN
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 48-153 aa (Q9Y534) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 13.24 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 13 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"