-
Product Name
Recombinant CP2AD protein (His tag)
- Documents
-
Description
Recombinant Human Cytochrome P450 2A13 (CYP2A13) fragment (residues 1-494) is a high-purity protein designed for structural and biochemical studies. This fragment encompasses the full-length protein and is optimized for stability and solubility, facilitating research into its enzymatic activities, including coumarin 7-hydroxylation and metabolic activation of carcinogens.
Cytochrome P450 2A13 (CYP2A13) is a human enzyme localized to the endoplasmic reticulum and microsome membranes as a peripheral membrane protein. It plays a critical role in xenobiotic metabolism, exhibiting coumarin 7-hydroxylase activity and participating in the metabolic activation of various compounds, such as the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, hexamethylphosphoramide, and N,N-dimethylaniline. Additionally, it demonstrates phenacetin O-deethylation activity, highlighting its importance in drug metabolism and toxicology research related to environmental and chemical exposures.
-
Protein name
Cytochrome P450 2A13
-
Uniprot ID
Q16696
-
Gene Name
CYP2A13
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 1-494 aa (Q16696) were fused with 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 58.35 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 58 kDa band.
-
Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"