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Recombinant CP21A protein (His tag)

Recombinant CP21A protein (His tag)

Cat.#: 546716

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Special Price 294.7 USD

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Product Information

  • Product Name
    Recombinant CP21A protein (His tag)
  • Documents
  • Description

    This product is a recombinant fragment of Steroid 21-hydroxylase (CYP21A2), encompassing amino acids 1-495, designed for robust structural and biochemical studies. It represents a stable, soluble unit of this key cytochrome P450 enzyme, facilitating research into adrenal steroidogenesis pathways.

    Steroid 21-hydroxylase (CYP21A2) is a cytochrome P450 monooxygenase essential for adrenal steroidogenesis in humans. It catalyzes the C-21 hydroxylation of progesterone and 17α-hydroxyprogesterone to produce 11-deoxycorticosterone and 11-deoxycortisol, critical intermediates in the synthesis of mineralocorticoids and glucocorticoids. The enzyme utilizes molecular oxygen and NADPH via cytochrome P450 reductase for its catalytic activity. It is localized to the endoplasmic reticulum and microsome membranes as a peripheral membrane protein, underscoring its role in steroid hormone biosynthesis.

  • Protein name
    Steroid 21-hydroxylase
  • Uniprot ID
    P08686
  • Gene Name
    CYP21A2; CYP21; CYP21B
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 1-495 aa (P08686) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 57.66 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 58 kDa band.
  • Purity
    >88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"