Recombinant COX5A protein (His tag)

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Recombinant Human COX5A Protein Fragment (42-150) is a high-purity, soluble fragment of Cytochrome c oxidase subunit 5A, mitochondrial, designed for structural and biochemical studies. This fragment represents a stable domain of the protein, facilitating research into mitochondrial electron transport chain mechanisms and oxidative phosphorylation.

Cytochrome c oxidase subunit 5A is a key component of cytochrome c oxidase (complex IV), the terminal enzyme in the mitochondrial electron transport chain responsible for reducing oxygen to water during oxidative phosphorylation. This process generates an electrochemical gradient that drives ATP synthesis, essential for cellular energy production. The full-length protein is localized to the mitochondrial inner membrane on the matrix side, where it functions as a peripheral membrane protein, contributing to electron transfer from cytochrome c to molecular oxygen via copper and heme centers. The provided fragment (42-150) encompasses a computationally predicted stable and soluble region, enabling detailed analysis of its structural and functional properties in respiratory chain studies.