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  • Cortistatin-17 (human) peptide

Cortistatin-17 (human) peptide

Not For Human Use, Lab Use Only.

Cat.#: 309021

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Product Information

  • Product Name
    Cortistatin-17 (human) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    DRMPCRNFFWKTFSSCK (Disulfide bridge: Cys5-Cys16)
  • Sequence
    H-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (Disulfide bridge: Cys5-Cys16)
  • Length (aa)
    17
  • Peptide Purity (HPLC)
    95.22%
  • Molecular Formula
    C96H139N27O24S3
  • Molecular Weight
    2151.53
  • CAS No.
    189450-19-9
  • Source
    Synthetic
  • Form
    Powder
  • Description
    This peptide with structural similarities to somatostatin binds to all somatostatin receptor subtypes (SSTR) in a similar way as the rat cortistatin. Its inhibitory effects on forskolin-stimulated cAMP production in chinese hamster ovary cells expressing SSTR2-5 are dose dependent but slightly less efficient than that of somatostatin-14. Like the rat cortistatin it has an effect on sleep and wakefulness pattern in rat. It decreases the light slow wave sleep (SWS1) and increases the deep slow wav
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • L.de Lecea, Genomics, 42, 499 (1997)
    • S.Fukusumi et al., Biochem. Biophys. Res. Commun., 232, 157 (1997)
    • Clynen E, Swijsen A, Raijmakers M, Hoogland G, Rigo JM. Neuropeptides as targets for the development of anticonvulsant drugs. Mol Neurobiol. 2014 Oct;50(2):626-46. doi: 10.1007/s12035-014-8669-x. Epub 2014 Apr 6. PMID: 24705860; PMCID: PMC4182642.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight

Peptide Property

  • Analysed Sequence:H-DRMPCRNFFWKTFSSCK-OH
  • Chemical Formula:C96H139N27O24S3
  • Sequence length:17
  • Extinction coefficient:5810 M-1cm-1
  • GRAVY:-0.78
  • Mw average:2151.48
  • Theoretical pI:9.91
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"