CMX-8933 peptide

CMX-8933 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-KKETLQFR-OH

H-Lys-Lys-Glu-Thr-Leu-Gln-Phe-Arg-OH

8

95.48%

C₄₇H₈₀N₁₄O₁₃

1049.22

146877-90-9

11457457

Synthetic

Powder

CMX-8933 is an 8-amino acid peptide fragment of Ependymin, a goldfish brain glycoprotein. CMX-8933 has the function of activating the AP-1 transcription factor in both mouse neuroblastoma (NB2a) and primary rat brain cortical cell cultures. In NB2a cells, a 13–14-fold increase in AP-1’s DNA binding was obtained with 6–10 mg/ml CMX-8933 after 4 h incubation, and in primary rat brain cortical cultures, a 26.7 ± 5.2-fold increase in binding was observed with as little as 10 ng/ml peptide after 3 h treatment. The activation of AP-1 transcription factor by CMX-8933 is rapid and transient, and it may play a role in transcriptional control, which is characteristic of full-sized neurotrophic factors in neuronal differentiation and regeneration. This suggests a potential role for Ependymin, from which CMX-8933 is derived, in transcriptional control and neuroplasticity.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Shashoua VE, Adams D, Boyer-Boiteau A. CMX-8933, a peptide fragment of the glycoprotein ependymin, promotes activation of AP-1 transcription factor in mouse neuroblastoma and rat cortical cell cultures. Neurosci Lett. 2001 Oct 19;312(2):103-7. doi: 10.1016/s0304-3940(01)02119-x. PMID: 11595345.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.