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Recombinant CL12B protein (His tag)

Cat.#: 545078

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Product Information

  • Product Name
    Recombinant CL12B protein (His tag)
  • Documents
  • Description

    Recombinant Human CLEC12B (C-type lectin domain family 12 member B) Fragment (aa 65-276): A high-purity protein fragment encompassing the full C-type lectin domain, designed for investigating immune regulation, inhibitory signaling, and melanocyte differentiation mechanisms.

    C-type lectin domain family 12 member B (CLEC12B), also known as Macrophage antigen H, is an inhibitory receptor that negatively regulates immune and non-immune functions. Upon phosphorylation, it recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases via its ITIM motif to antagonize activation signals. It limits myeloid cell activation during infection or inflammation, protects target cells against natural killer cell-mediated lysis, and negatively regulates melanocyte cell cycle and differentiation through STAT3 inactivation. The protein is localized to the cell membrane as a single-pass type II membrane protein. The recombinant fragment (aa 65-276) includes the complete C-type lectin domain (aa 150-264), enabling focused

  • Protein name
    C-type lectin domain family 12 member B
  • Uniprot ID
    Q2HXU8
  • Gene Name
    CLEC12B
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 65-276 aa (Q2HXU8) were fused with C-terminal 6His tag.
  • Sequence 
    MSKIKLQISN DINSDSEKLS QLQKTIQQQQ DNLSQQLGNS NNLSMEEEFL KSQISSVLKR QEQMAIKLCQ ELIIHTSDHR
CNPCPKMWQW YQNSCYYFTT NEEKTWANSR KDCIDKNSTL VKIDSLEEKD FLMSQPLLMF SFFWLGLSWD SSGRSWFWED
GSVPSPSLFS TKELDQINGS KGCAYFQKGN IYISRCSAEI FWICEKTAAP VKTEDLDLEH HHHHH
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 26.25 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 27 kDa band.
  • Purity
    >90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant CL12B protein (His tag) SDS-PAGE

    Recombinant CL12B protein (His tag) SDS-PAGE

    M: Marker; Lane 1: CL12B; Lane 2: BSA

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"