Champacyclin peptide

Champacyclin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

KIIFLIAI

Lys-Ile-Ile-D-Phe-D-Leu-Ile-D-Ala-D-Allo-Ile (head-to-tail cyclic)

8

96.6%

C₄₈H₈₁N₉O₈

912.22

Synthetic

Powder

This head-to-tail cyclic peptide is likely synthesized by a non-ribosomal peptide synthetase (NRPS) since F4, L5, A7 and I8 are all D-amino acids. Active against C. glabrata and E. amylovora (at 25 uM). E. amylovora is responsible for Fire blight (fireblight) that is a contagious disease affecting apples, pears, etc. The source of Champacyclin is marine sediments of the Gotland Deep (Baltic Sea), Streptomyces champavatii.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Pesic A, Baumann HI, Kleinschmidt K, Ensle P, Wiese J, Süssmuth RD, Imhoff JF. Champacyclin, a new cyclic octapeptide from Streptomyces strain C42 isolated from the Baltic Sea. Mar Drugs. 2013 Dec 2;11(12):4834-57. doi: 10.3390/md11124834. PMID: 24317473; PMCID: PMC3877890.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.