α-CGRP (human) peptide

α-CGRP (human) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2

H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2

37

95.19%

C₁₆₃H₂₆₇N₅₁O₄₉S₂

3789.29

Synthetic

Powder

α-Calcitonin gene related peptide (human) is a potent, long-lasting vasodilator which possesses protective mechanisms for physiological and pathological conditions involving the cardiovascular system and wound healing. CGRP is primarily released from sensory nerves and can function in the transmission of nociception. α-Calcitonin gene related peptide (human) acts as an appetite suppressant and contributes to gastric acid secretion.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Brain et al (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313 54 PMID: 3917554
• Poyner et al (2002) International union of pharmacology XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol.Revs. 54 233 PMID: 12037140
• Russell et al (2014) Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 94(4) 1099 PMID: 25287861

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.