CGN peptide

CGN peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-cgnhphlakyngt-OH, All D-type Amino acids

H-d-Cys-d-Gly-d-Asn-d-His-d-Pro-d-His-d-Leu-d-Ala-d-Lys-d-Tyr-d-Asn-d-Gly-d-Thr-OH

13

95.6%

C₆₀H₉₀N₂₀O₁₈S

1411.55

Synthetic

Powder

CGN is a peptide with the sequence d-CGNHPHLAKYNGT. It is the retro-inverso isomer of the TGN peptide. Previous study found that the TGN peptide facilitated polyethylene glycol-polylactide-polyglycolide (PEG-PLGA) nanoparticles across the blood-brain barrier (BBB), leading to significant higher brain accumulation. And CGN peptide exhibits higher brain targeting than that of TGN. It is used as a BBB targeting carrier.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Wang P, Zheng X, Guo Q, Yang P, Pang X, Qian K, Lu W, Zhang Q, Jiang X. Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease. J Control Release. 2018 Jun 10;279:220-233. doi: 10.1016/j.jconrel.2018.04.034. Epub 2018 Apr 19. PMID: 29679667.
• Zheng X, Pang X, Yang P, Wan X, Wei Y, Guo Q, Zhang Q, Jiang X. A hybrid siRNA delivery complex for enhanced brain penetration and precise amyloid plaque targeting in Alzheimer's disease mice. Acta Biomater. 2017 Feb;49:388-401. doi: 10.1016/j.actbio.2016.11.029. Epub 2016 Nov 11. PMID: 27845275.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.