CGKRK peptide

CGKRK peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-CGKRK-OH

H-Cys-Gly-Lys-Arg-Lys-OH

5

95.68%

C₂₃H₄₆N₁₀O₆S

590.74

Synthetic

Powder

CGKRK is a tumor homing peptide, discovered by phage display technique. It mediates the cellular internalization in energy and heparin sulfate receptor-dependent manner. Then it localizes to mitochondria in cells. CGKRK peptide exhibited selective high binding affinity to the neovascular endothelial cells and tumor tissues, but not to the non-tumorigenic cells.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Hu, Q. et al. CGKRK-modified nanoparticles for dual-targeting drug delivery to tumor cells and angiogenic blood vessels. Biomaterials 34, 9496-9508 (2013).
• Hoffman, J. A. et al. Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma. Cancer Cell 4, 383-391 (2003).
• Jarvinen, T. A. & Ruoslahti, E. Molecular changes in the vasculature of injured tissues. Am. J. Pathol. 171, 702-11 (2007).

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.