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Product Name
Recombinant CF298 protein (His tag)
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Description
Recombinant Human CFAP298 (Protein kurly homolog) fragment (residues 1-290) is a high-quality protein product designed for structural and biochemical studies. This fragment represents a stable and soluble unit of the protein, ideal for investigating its role in motile cilium function and dynein arm assembly.
Cilia- and flagella-associated protein 298 (CFAP298), also known as Protein kurly homolog, plays a critical role in motile cilium function, likely by contributing to outer dynein arm assembly. It appears essential for initiating cilium motility rather than maintaining it and is required for proper apical positioning of cilia, indicating involvement in the planar cell polarity (PCP) pathway. Additionally, CFAP298 may function in suppressing canonical Wnt signaling. Subcellular localization studies show its presence in the cytoplasm and at the cilium basal body, with partial colocalization in cytoplasmic puncta suggesting centrosomal association, underscoring its importance in cellular structure and signaling pathways.
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Protein name
Cilia- and flagella-associated protein 298
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Uniprot ID
P57076
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Gene Name
CFAP298; C21orf48; C21orf59
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-290 aa (P57076) were fused with 6His tag.
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Sequence
1-290
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 34.88 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 38 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"