Recombinant CENPM protein (His tag)

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This recombinant protein product features a stable and soluble fragment (amino acids 1-180) of human Centromere protein M (CENP-M), also known as Interphase centromere complex protein 39 or Proliferation-associated nuclear element protein 1. This fragment is designed for structural and biochemical studies, offering researchers a functional unit ideal for investigating kinetochore assembly and chromosome segregation mechanisms.

Centromere protein M (CENP-M) is a key component of the CENPA-NAC (nucleosome-associated) complex, which plays a central role in kinetochore assembly, mitotic progression, and chromosome segregation. This complex facilitates the recruitment of the CENPA-CAD (nucleosome distal) complex and may contribute to the incorporation of newly synthesized CENPA into centromeres. CENP-M localizes to the nucleus in non-confluent cells and the cytoplasm in confluent or dividing cells, with specific localization in the kinetochore domain of centromeres, underscoring its importance in cell division and genomic stability.