Cecropin A (1-7)-Melittin A (2-9) amide, CAMEL/CM15 peptide

Cecropin A (1-7)-Melittin A (2-9) amide, CAMEL/CM15 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

KWKLFKKIGAVLKVL-NH2

H-Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-NH2

15

96.65%

C₈₉H₁₅₂N₂₂O₁₅

1770.31

Synthetic

Powder

Cecropin A (1-7)-Melittin A (2-9) amide, also referred to as CAMEL0, is a synthetic hybrid peptide that is composed of portions of the naturally occurring antibiotic peptide cecropin A and melittin. CAMEL0 shows a better antimicrobial activity than the native molecules, but lacks the hemolytic properties of melittin. Studies revealed that the range of its antimicrobial activity is not only restricted to aerobic microorganisms but also included several gram-negative and gram-positive anaerobic mi

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• H.Oh et al., Antimicrob. Agents Chemother., 44, 68 (2000)
• Chicharro C, Granata C, Lozano R, Andreu D, Rivas L. N-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide. Antimicrob Agents Chemother. 2001;45(9):2441-2449. doi:10.1128/AAC.45.9.2441-2449.2001
• Ma L, Huang S, Xie H, et al. Influence of chain length on the anticancer activity of the antimicrobial peptide CAMEL with fatty acid modification. Eur J Med Chem. 2022;239:114557. doi:10.1016/j.ejmech.2022.114557

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.