Recombinant CEBPA protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Introducing the recombinant human CCAAT/enhancer-binding protein alpha (C/EBP alpha) fragment (amino acids 276-358), a precisely engineered 83-amino acid protein containing the complete bZIP functional domain. This high-purity fragment serves as an essential research tool for investigating the DNA-binding and dimerization mechanisms central to C/EBP alpha's role as a master regulator of cell differentiation and metabolic processes.

CCAAT/enhancer-binding protein alpha (C/EBP alpha) is a critical transcription factor that coordinates proliferation arrest and differentiation in multiple cell lineages, including myeloid progenitors, adipocytes, and hepatocytes. It binds to specific DNA sequences (5'-T[TG]NNGNAA[TG]-3') to activate target genes involved in myeloid development, adipocyte differentiation, and metabolic regulation such as gluconeogenesis and lipogenesis. The protein functions through interactions with other regulatory factors including FOXO1 and SREBF1, and localizes primarily to the nucleus where it regulates gene expression programs. The bZIP domain contained within this fragment (amino acids 282-345) mediates both DNA binding and protein dimerization, making this recombinant protein particularly valuable for studying the structural and functional aspects of C/EBP alpha's transcriptional regulatory mechanisms.