Recombinant CCNE2 protein (His tag)

• DataSheet
• COA (Batch NP456395)
• Material Safety Data Sheets (MSDS)

Recombinant G1/S-specific cyclin-E2 (CCNE2) fragment (residues 99-404) from Homo sapiens, designed for structural and biochemical studies. This 306-amino acid fragment represents a stable and soluble unit essential for cell cycle regulation at the G1/S transition, ideal for investigating mechanisms of cell proliferation.

G1/S-specific cyclin-E2, encoded by the CCNE2 gene, is critical for controlling the cell cycle during the late G1 and early S phases, as supported by multiple references (PubMed:9840927, PubMed:9840943, PubMed:9858585). It localizes to the nucleus, where it facilitates key transitions in cell division, underscoring its importance in cellular replication and potential relevance in cancer research. The selected fragment (99-404) was computationally optimized for stability and solubility, enabling detailed analysis of its functional properties without the full-length protein's complexities.

MPSPLPDLSW GCSKEVWLNM LKKESRYVHD KHFEVLHSDL EPQMRSILLD WLLEVCEVYT LHRETFYLAQ DFFDRFMLTQ
KDINKNMLQL IGITSLFIAS KLEEIYAPKL QEFAYVTDGA CSEEDILRME LIILKALKWE LCPVTIISWL NLFLQVDALK
DAPKVLLPQY SQETFIQIAQ LLDLCILAID SLEFQYRILT AAALCHFTSI EVVKKASGLE WDSISECVDW MVPFVNVVKS
TSPVKLKTFK KIPMEDRHNI QTHTNYLAML EEVNYINTFR KGGQLSPVCN GGIMTPPKST EKPPGKHLEH HHHHH