Recombinant CC134 protein (His tag)

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Recombinant Human Coiled-coil domain-containing protein 134 (CCDC134) Fragment (aa 23-229) is a highly stable and soluble protein unit ideal for structural and biochemical studies. This fragment captures essential functional regions of CCDC134, enabling research into its roles as a molecular adapter in protein folding, immune modulation, and signaling regulation.

CCDC134 is a multifunctional human protein that primarily localizes to the endoplasmic reticulum lumen, with additional presence in secreted form, cytoplasm, and nucleus. It serves as a critical molecular adapter that prevents hyperglycosylation of HSP90B1 during translation by tethering it to specialized translocons, ensuring proper folding and preventing degradation. Beyond its ER functions, secreted CCDC134 promotes CD8+ T-cell proliferation and activation, suggesting cytokine-like activity. It also modulates ERK and JNK signaling pathways, suppressing cell migration and invasion. Nuclear localization under stress conditions reveals its role in stabilizing the PCAF histone acetyltransferase complex, while it additionally regulates osteogenesis and bone development. This protein's diverse subcellular distribution underscores its importance in cellular homeostasis, immune response, and developmental processes.