cathelicidin-OA1 peptide

cathelicidin-OA1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-IGRDPTWSHLAASCLKCIFDDLPKTHN-OH

H-Ile-Gly-Arg-Asp-Pro-Thr-Trp-Ser-His-Leu-Ala-Ala-Ser-Cys-Leu-Lys-Cys-Ile-Phe-Asp-Asp-Leu-Pro-Lys-Thr-His-Asn-OH

27

95.99%

C₁₃₄H₂₀₆N₃₈O₃₉S₂

3037.42

Synthetic

Powder

Cathelicidins play pivotal roles in host defense. Cathelicidin-OA1 is a Cathelicidin identified from the skin of an amphibian species, Odorrana andersonii. Cathelicidin-OA1 showed no direct microbe-killing, acute toxicity and hemolytic activity, but did exhibit antioxidant activity. Cathelicidin-OA1 accelerated wound healing against human keratinocytes (HaCaT) and skin fibroblasts (HSF) in both time- and dose-dependent manners. Cathelicidin-OA1 also showed wound-healing promotion in a mouse model with full-thickness skin wounds, accelerating re-epithelialization and granulation tissue formation by enhancing the recruitment of macrophages to the wound site, inducing HaCaT cell proliferation and HSF cell migration.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Cao X, Wang Y, Wu C, Li X, Fu Z, Yang M, Bian W, Wang S, Song Y, Tang J, Yang X. Cathelicidin-OA1, a novel antioxidant peptide identified from an amphibian, accelerates skin wound healing. Sci Rep. 2018 Jan 17;8(1):943. doi: 10.1038/s41598-018-19486-9. Erratum in: Sci Rep. 2018 Oct 23;8(1):15906. PMID: 29343843; PMCID: PMC5772731.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.