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Product Name
Recombinant C4BPB protein (His tag)
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Description
Recombinant Human C4b-binding protein beta chain fragment (amino acids 18-252) is a high-purity protein designed for studying the functional roles of the Sushi domains in complement regulation and protein S binding. This fragment provides researchers with a targeted tool to investigate specific domain interactions and mechanisms.
The full-length C4b-binding protein beta chain, encoded by the C4BPB gene in humans, is a secreted protein that plays a critical role in controlling the classical pathway of complement activation. It functions as a cofactor for C3b/C4b inactivator (C3bINA), facilitating the hydrolysis of complement fragment C4b and accelerating the degradation of the C4bC2a complex (C3 convertase) by dissociating C2a. Additionally, it interacts with anticoagulant protein S—a binding mediated by the beta chain—and with serum amyloid P component, highlighting its importance in immune regulation and coagulation processes.
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Protein name
C4b-binding protein beta chain
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Uniprot ID
P20851
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Gene Name
C4BPB
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 18-252 aa (P20851) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 28.01 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 30 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"