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Product Name
Recombinant BROMI protein (His tag)
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Description
Introducing the recombinant Protein broad-minded (TBC1D32) fragment (residues 1-134), a highly stable and soluble protein unit ideal for structural and biochemical studies. This fragment, derived from human TBC1D32, supports research into ciliary function and Sonic Hedgehog (Shh) signaling pathways, offering researchers a reliable tool for exploring neural development and cellular mechanisms.
The full-length Protein broad-minded (TBC1D32) is essential for high-level Shh responses during neural tube development. It collaborates with CDK20 to regulate primary cilium structure by coordinating the assembly of the ciliary membrane and axoneme, facilitating proper activation of GLI2 in response to Shh signaling. This protein is localized in the cytoplasm and cell projections, specifically cilia, underscoring its critical role in ciliary function and developmental processes.
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Protein name
Protein broad-minded
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Uniprot ID
Q96NH3
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Gene Name
TBC1D32; BROMI; C6orf170; C6orf171
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-134 aa (Q96NH3) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 17.39 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 20 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"