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  • Brevinin-1LT2 peptide

Brevinin-1LT2 peptide

Not For Human Use, Lab Use Only.

Cat.#: 300664

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Brevinin-1LT2 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-FFGSVLKVAAKVLPAALCQIFKKC-OH
  • Sequence
    H-Phe-Phe-Gly-Ser-Val-Leu-Lys-Val-Ala-Ala-Lys-Val-Leu-Pro-Ala-Ala-Leu-Cys-Gln-Ile-Phe-Lys-Lys-Cys-OH (disulfide bond: Cys18-Cys24)
  • Length (aa)
    24
  • Peptide Purity (HPLC)
    95.21%
  • Molecular Formula
    C123H199N29O27S2
  • Molecular Weight
    2580.25
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Brevinin-1LT2 is a novel antimicrobial peptide identified from the skin secretions of the Chinese broad-folded frog, Hylarana latouchii. It belongs to the brevinin-1 family of amphibian antimicrobial peptides, which are characterized by a conserved amino acid sequence and the presence of a disulfide bridge forming a C-terminal loop. The primary structure of brevinin-1LT2 is FFGSVLKVAAKVLPAALCQIFKKC.

    This peptide is predicted to adopt an amphipathic alpha-helical conformation, a structural feature common among antimicrobial peptides that enables interaction with and disruption of microbial cell membranes. Brevinin-1LT2 displays a high content of alpha-helical secondary structure, a net positive charge of +4, and a grand average of hydropathicity (GRAVY) of 1.133. These physicochemical properties are closely similar to those of brevinin-1LT1, suggesting that brevinin-1LT2 likely possesses analogous membrane-disturbing antimicrobial mechanisms.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Wang H, Yan X, Yu H, et al. Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae). Biochimie. 2009;91(4):540-7.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"