Bradykinin-potentiating peptide Phypo Xa

Bradykinin-potentiating peptide Phypo Xa

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Pyroglutamic acid Pyr-FRPSYQIPP-OH

Pyroglutamic acid Pyr-Phe-Arg-Pro-Ser-Tyr-Gln-Ile-Pro-Pro-OH

10

95.44%

C₅₈H₈₂N₁₄O₁₅

1215.35

Synthetic

Powder

Bradykinin-potentiating peptide Phypo Xa is a type of Bradykinin potentiating peptides (BPPs) isolated from the skin secretion of the Brazilian tree-frog Phyllomedusa hypochondrialis, and is the first canonical BPP to be found not only in the frog skin but also in any other natural souce other than the snake venoms.
Bradykinin-potentiating peptide Phypo Xa can potentiate bradykinin activities in vivo and in vitro, as well as efficiently and competitively inhibit ACE. Besides, it presents a classical motif and can be recognized by its typical pyroglutamyl(Pyr)/proline-rich sequences invariably presenting a proline residue at the C-terminus as other BPPs.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Conceição K, Konno K, De melo RL, et al. Isolation and characterization of a novel bradykinin potentiating peptide (BPP) from the skin secretion of Phyllomedusa hypochondrialis. Peptides. 2007;28(3):515-23.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.